Cell Culture Ontology

Last uploaded: July 23, 2014
Preferred Name

heart

Synonyms

Herz

chambered heart

branchial heart

Entire heart

cardium

Herz@de

vertebrate heart

Definitions

a myogenic muscular organ found in the cardiovascular system. It is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. The vertebrate heart is composed of cardiac muscle, which is an involuntary striated muscle tissue found only in this organ, and connective tissue. Primitive fish have a four-chambered heart; however, the chambers are arranged sequentially so that this primitive heart is quite unlike the four-chambered hearts of mammals and birds. The first chamber is the sinus venosus, which collects de-oxygenated blood, from the body, through the hepatic and cardinal veins. From here, blood flows into the atrium and then to the powerful muscular ventricle where the main pumping action takes place. The fourth and final chamber is the conus arteriosus which contains several valves and sends blood to the ventral aorta. The ventral aorta delivers blood to the gills where it is oxygenated and flows, through the dorsal aorta, into the rest of the body. (In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary artery. In the adult fish, the four chambers are not arranged in a straight row but, instead, form an S-shape with the latter two chambers lying above the former two. This relatively simpler pattern is found in cartilaginous fish and in the more primitive ray-finned fish. In teleosts, the conus arteriosus is very small and can more accurately be described as part of the aorta rather than of the heart proper. The conus arteriosus is not present in any amniotes which presumably having been absorbed into the ventricles over the course of evolution. Similarly, while the sinus venosus is present as a vestigial structure in some reptiles and birds, it is otherwise absorbed into the right atrium and is no longer distinguishable[WP]. note that we use the term 'circulatory organ' for the generic class. Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepi- thelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" doi:10.1101/gad.1485706 A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706

ID

http://purl.obolibrary.org/obo/UBERON_0000948

comment

note that we use the term 'circulatory organ' for the generic class. Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepi- thelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" doi:10.1101/gad.1485706

Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706

axiom_lost_from_external_ontology

relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]

database_cross_reference

XAO:0000064

Wikipedia:Heart

EHDAA2:0000738

OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA

galen:Heart

MAT:0000036

EFO:0000815

SNOMEDCT:302509004

EHDAA:420

MA:0000072

TAO:0000114

GAID:174

UMLS:C0018787

EV:0100018

BILA:0000020

MESH:A07.541

NCIT:C12727

EMAPA:16105

AAO:0010210

MIAA:0000036

CALOHA:TS-0445

FMA:7088

VHOG:0000276

NCIt:C12727

MSH:D006321

BTO:0000562

MESH:D006321

ZFA:0000114

http://linkedlifedata.com/resource/umls/id/C0018787

http://en.wikipedia.org/wiki/Heart

http://www.snomedbrowser.com/Codes/Details/302509004

definition

a myogenic muscular organ found in the cardiovascular system. It is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. The vertebrate heart is composed of cardiac muscle, which is an involuntary striated muscle tissue found only in this organ, and connective tissue. Primitive fish have a four-chambered heart; however, the chambers are arranged sequentially so that this primitive heart is quite unlike the four-chambered hearts of mammals and birds. The first chamber is the sinus venosus, which collects de-oxygenated blood, from the body, through the hepatic and cardinal veins. From here, blood flows into the atrium and then to the powerful muscular ventricle where the main pumping action takes place. The fourth and final chamber is the conus arteriosus which contains several valves and sends blood to the ventral aorta. The ventral aorta delivers blood to the gills where it is oxygenated and flows, through the dorsal aorta, into the rest of the body. (In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary artery. In the adult fish, the four chambers are not arranged in a straight row but, instead, form an S-shape with the latter two chambers lying above the former two. This relatively simpler pattern is found in cartilaginous fish and in the more primitive ray-finned fish. In teleosts, the conus arteriosus is very small and can more accurately be described as part of the aorta rather than of the heart proper. The conus arteriosus is not present in any amniotes which presumably having been absorbed into the ventricles over the course of evolution. Similarly, while the sinus venosus is present as a vestigial structure in some reptiles and birds, it is otherwise absorbed into the right atrium and is no longer distinguishable[WP].

A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.

develops_from

http://purl.obolibrary.org/obo/UBERON_0004141

external_definition

Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]

Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]

has_exact_synonym

Herz

chambered heart

branchial heart

Entire heart

vertebrate heart

has_narrow_synonym

branchial heart

has_obo_namespace

uberon

has_related_synonym

cardium

Herz@de

has_relational_adjective

cardiac

homologous_in

http://purl.obolibrary.org/obo/NCBITaxon_7742

homology_notes

As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]

id

UBERON:0000948

in_subset

http://purl.obolibrary.org/obo/uberon#major_organ

http://purl.obolibrary.org/obo/uberon#efo_slim

http://purl.obolibrary.org/obo/uberon/core#major_organ

http://purl.obolibrary.org/obo/uberon#vertebrate_core

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#organ_slim

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#efo_slim

http://purl.obolibrary.org/obo/uberon#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#vertebrate_core

http://purl.obolibrary.org/obo/uberon#organ_slim

label

heart

notation

UBERON:0000948

part_of

http://purl.obolibrary.org/obo/UBERON_0004535

prefLabel

heart

treeView

http://purl.obolibrary.org/obo/UBERON_0004535

http://purl.obolibrary.org/obo/UBERON_0004141

subClassOf

http://purl.obolibrary.org/obo/UBERON_0005181

http://purl.obolibrary.org/obo/UBERON_0007100

http://purl.obolibrary.org/obo/UBERON_0010314

http://purl.obolibrary.org/obo/UBERON_0004120

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Delete Mapping To Ontology Source
http://www.co-ode.org/ontologies/galen#Heart GALEN LOOM
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urn:absolute:RadiationOncologyStructuresOntology#Heart ROS LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5865 OCHV LOOM
http://www.projecthalo.com/aura#Heart AURA LOOM
http://doe-generated-ontology.com/OntoAD#C0018787 ONTOAD LOOM
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http://purl.obolibrary.org/obo/HaauraA_0000628 HAAURAADO LOOM
http://purl.obolibrary.org/obo/MA_0000072 MA LOOM
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http://www.semanticweb.org/ontologies/2010/10/BPO.owl#heart BHO LOOM
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http://purl.jp/bio/4/id/200906048777636790 IOBC LOOM
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http://scai.fraunhofer.de/CSEO#Heart CSEO LOOM
http://purl.obolibrary.org/obo/EHDA_7379 EHDA LOOM
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