Cell Culture Ontology

Last uploaded: July 23, 2014
Preferred Name

cholesterol

Synonyms

Cytochrome P450 CYP8B1

Epicholesterol

[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C

Steroid 12-Alpha-Hydroxylase

Cholest-5-en-3-ol (3beta)-

Cytochrome P450 8B1

Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1

CYPVIIIB1

Cholesterin

C27H46O

Sterol 12 Alpha Hydroxylase

Cholest-5-en-3beta-ol

InChIKey=HVYWMOMLDIMFJA-DPAQBDIFBB

7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase

InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

CYP8B1

Cytochrome P450 Family 8 Subfamily B Polypeptide 1

Definitions

Encoded by human CYP8B1 Gene (Cytochrome P450 Family), 501-aa 58-kDa Cytochrome P450 8B1 is a liver endoplasmic reticulum membrane P450 heme-thiolate monooxygenase involved in bile acid synthesis that catalyzes conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these steroids determines the relative amount of cholic and chenodeoxycholic acids secreted in the bile that affect cholesterol solubility. CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI) The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. A cholestanoid that has formula C27H46O.

ID

http://purl.obolibrary.org/obo/CHEBI_16113

database_cross_reference

MSH:D002784

NCIt:C369

SNOMEDCT:84698008

definition

Encoded by human CYP8B1 Gene (Cytochrome P450 Family), 501-aa 58-kDa Cytochrome P450 8B1 is a liver endoplasmic reticulum membrane P450 heme-thiolate monooxygenase involved in bile acid synthesis that catalyzes conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these steroids determines the relative amount of cholic and chenodeoxycholic acids secreted in the bile that affect cholesterol solubility. CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.

A cholestanoid that has formula C27H46O.

definition_citation

(3beta)-cholest-5-en-3-ol

57-88-5

2401

C27H46O

22401

gwas_trait

true

has_exact_synonym

Cytochrome P450 CYP8B1

Epicholesterol

[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C

Steroid 12-Alpha-Hydroxylase

Cholest-5-en-3-ol (3beta)-

Cytochrome P450 8B1

Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1

CYPVIIIB1

Cholesterin

C27H46O

Sterol 12 Alpha Hydroxylase

Cholest-5-en-3beta-ol

InChIKey=HVYWMOMLDIMFJA-DPAQBDIFBB

7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase

InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

CYP8B1

Cytochrome P450 Family 8 Subfamily B Polypeptide 1

label

cholesterol

prefixIRI

CHEBI:16113

prefLabel

cholesterol

term editor

Tomasz Adamusiak

subClassOf

http://www.ebi.ac.uk/efo/EFO_0003836

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http://purl.bioontology.org/ontology/LNC/LP15493-7 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D002784 MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0008377 ONTOAD LOOM
http://purl.jp/bio/10/gmo/GMO_001821 GMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.247.222.284 RH-MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB04540 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.247.808.197 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00723185 DRON LOOM
http://www.co-ode.org/ontologies/galen#Cholesterol GALEN LOOM
http://scai.fraunhofer.de/MSOntology#Cholesterol MSO LOOM
http://purl.bioontology.org/ontology/NDDF/002556 NDDF LOOM
http://id.loc.gov/authorities/subjects/sh85024654 FAST-TOPICAL LOOM
http://www.semanticweb.org/ADMO#cholesterol ADMO LOOM
http://purl.bioontology.org/ontology/LNC/LP100019-1 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/2438 RXNORM LOOM
http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Cholesterol PCALION LOOM
http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Cholesterol PCALION LOOM
http://stirdf.jst.go.jp/id/200907040526382996 IOBC LOOM
http://stirdf.jst.go.jp/id/200907040526382996 IOBC LOOM
http://stirdf.jst.go.jp/id/200907040526382996 IOBC LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0008377 MEDLINEPLUS LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146961 NDFRT LOOM
http://www.pepathway.org/peo/1.2#cholesterol PE-O LOOM
http://scai.fraunhofer.de/CSEO#CSEO_00000455 CSEO LOOM
http://purl.bioontology.org/ontology/VANDF/4018648 VANDF LOOM
http://purl.obolibrary.org/obo/UPa_UPC00187 UPA LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003147 LOINC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Cholesterol APAONTO LOOM
http://localhost/plosthes.2017-1#8788 PLOSTHES LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369 NCIT LOOM
http://purl.bioontology.org/ontology/MEDDRA/10008650 MEDDRA LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 TXPO LOOM
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http://purl.obolibrary.org/obo/CHEBI_16113 HUPSON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_16113 IDOBRU LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 IDOBRU SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 EFO LOOM
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http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_16113 TXPO LOOM
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http://purl.obolibrary.org/obo/CHEBI_16113 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 UPHENO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 ZP LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 ZP SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI SAME_URI
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http://purl.obolibrary.org/obo/CHEBI_16113 HINO SAME_URI
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http://purl.obolibrary.org/obo/CHEBI_16113 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_16113 ONSTR LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 ONSTR SAME_URI
http://purl.bioontology.org/ontology/SNOMEDCT/84698008 SNOMEDCT LOOM
http://www.projecthalo.com/aura#Cholesterol AURA LOOM
http://scai.fraunhofer.de/AlzheimerOntology#cholesterol ADO LOOM
http://purl.bioontology.org/ontology/CSP/0658-4141 CRISP LOOM
http://purl.jp/bio/4/id/200906081386040806 IOBC LOOM
http://purl.jp/bio/4/id/200906081386040806 IOBC LOOM
http://purl.jp/bio/4/id/200906081386040806 IOBC LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Cholesterol PCAO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002784 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/X80Iz RCD LOOM
http://purl.bioontology.org/ontology/SNMI/F-63980 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.570.938.208 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.851.208 RH-MESH LOOM