loading...| Preferred Name |
trioxsalen |
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| Synonyms |
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| Definitions |
7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_28329 |
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| alternative term |
InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 Trioxsalen InChIKey=FMHHVULEAZTJMA-UHFFFAOYSA-N Trioxysalen 4,5',8-Trimethylpsoralen 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one trioxysalen Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 Trimethylpsoralen 4,8,5'-Trimethylpsoralen trioxisaleno 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone 2',4,8-Trimethylpsoralen trioxysalene C14H12O3 trioxysalenum |
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| definition |
7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. |
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| has role | ||
| label |
trioxsalen |
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| prefixIRI |
CHEBI:28329 |
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| prefLabel |
trioxsalen |
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| subClassOf |