loading...| Preferred Name |
Gemcitabine Hydrochloride |
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| Synonyms |
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|
| Definitions |
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C961 |
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| Accepted_Therapeutic_Use_For |
Bladder cancer; Breast cancer; Carcinoma of unknown primary origin; Lung cancer; including non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Renal cell carcinoma |
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| ALT_DEFINITION |
A drug used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride blocks the cell from making DNA and may kill cancer cells. |
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| CAS_Registry |
122111-03-9 |
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| CHEBI_ID |
CHEBI:31647 |
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| Chemical_Formula |
C9H11F2N3O4.HCl |
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| code |
C961 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. |
|
| Display_Name |
Gemcitabine Hydrochloride |
|
| FDA_UNII_Code |
U347PV74IL |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Gemcitabine Hydrochloride |
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| Legacy Concept Name |
Gemcitabine |
|
| Maps_To |
Gemcitabine Hydrochloride |
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| NCI_Drug_Dictionary_ID |
41213 |
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| NSC Number |
613327 |
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| PDQ_Closed_Trial_Search_ID |
41213 |
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| PDQ_Open_Trial_Search_ID |
41213 |
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| Preferred_Name |
Gemcitabine Hydrochloride |
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| prefixIRI |
NCIT:C961 |
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| prefLabel |
Gemcitabine Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
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| UMLS_CUI |
C0771488 |
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| subClassOf |