Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Lucitanib
Synonyms
Definitions

A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
ID

http://purl.obolibrary.org/obo/NCIT_C95726
CAS_Registry

1058137-23-7
code

C95726
Contributing_Source

FDA
definition

A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
FDA_UNII_Code

PP449XA4BH
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Lucitanib
Maps_To

Lucitanib
NCI_Drug_Dictionary_ID

694590
PDQ_Closed_Trial_Search_ID

694590
PDQ_Open_Trial_Search_ID

694590
Preferred_Name

Lucitanib
prefixIRI

NCIT:C95726
prefLabel

Lucitanib
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C3887575
subClassOf

http://purl.obolibrary.org/obo/NCIT_C93259
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