loading...| Preferred Name | Levothyroxine Sodium | |
| Synonyms |
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| Definitions |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C888 |
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| CAS_Registry |
25416-65-3 |
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| Chemical_Formula |
C15H10I4NO4.Na.H2O |
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| code |
C888 |
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| Contributing_Source |
CTRP FDA PCDC |
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| definition |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. |
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| Display_Name |
Levothyroxine Sodium |
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| FDA_UNII_Code |
9J765S329G |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C186329 |
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| Is_Value_For_GDC_Property | ||
| label |
Levothyroxine Sodium |
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| Legacy Concept Name |
Therapeutic_Levothyroxine |
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| Maps_To |
Levothyroxine Sodium |
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| NCI_Drug_Dictionary_ID |
39298 |
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| NSC Number |
36397 |
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| PDQ_Closed_Trial_Search_ID |
39298 |
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| PDQ_Open_Trial_Search_ID |
39298 |
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| Preferred_Name |
Levothyroxine Sodium |
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| prefixIRI |
NCIT:C888 |
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| prefLabel |
Levothyroxine Sodium |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0079691 |
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| subClassOf |