loading...| Preferred Name |
Thioguanine |
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| Synonyms |
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|
| Definitions |
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C876 |
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| Accepted_Therapeutic_Use_For |
Acute nonlymphocytic leukemia |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
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| CAS_Registry |
154-42-7 5580-03-0 |
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| Chemical_Formula |
C5H5N5S.H2O |
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| code |
C876 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04) |
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| Display_Name |
Thioguanine |
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| FDA_UNII_Code |
FTK8U1GZNX |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Thioguanine |
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| Legacy Concept Name |
Thioguanine |
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| Maps_To |
Thioguanine |
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| NCI_Drug_Dictionary_ID |
43669 |
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| NSC Number |
752 |
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| PDQ_Closed_Trial_Search_ID |
43669 |
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| PDQ_Open_Trial_Search_ID |
43669 |
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| Preferred_Name |
Thioguanine |
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| prefixIRI |
NCIT:C876 |
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| prefLabel |
Thioguanine |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
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| UMLS_CUI |
C0039902 |
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| subClassOf |