loading...| Preferred Name |
Streptonigrin |
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| Synonyms |
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| Definitions |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C844 |
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| CAS_Registry |
3930-19-6 |
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| CHEBI_ID |
CHEBI:9287 |
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| Chemical_Formula |
C25H22N4O8 |
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| code |
C844 |
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| Contributing_Source |
FDA |
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| definition |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04) |
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| FDA_UNII_Code |
261Q3JB310 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Streptonigrin |
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| Legacy Concept Name |
Streptonigrin |
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| Maps_To |
Streptonigrin |
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| NCI_Drug_Dictionary_ID |
39703 |
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| NSC Number |
45383 83950 |
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| PDQ_Closed_Trial_Search_ID |
39703 |
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| PDQ_Open_Trial_Search_ID |
39703 |
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| Preferred_Name |
Streptonigrin |
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| prefixIRI |
NCIT:C844 |
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| prefLabel |
Streptonigrin |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
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| UMLS_CUI |
C0038427 |
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| subClassOf |