loading...| Preferred Name |
Rabeprazole Sodium |
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| Synonyms |
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| Definitions |
The sodium salt of the prodrug rabeprazole, a substituted benzimidazole proton pump inhibitor, with potential anti-ulcer activity. After protonation, accumulation, and transformation to the active sulfenamide within the acidic environment of gastric parietal cells, rabeprazole selectively and irreversibly binds to and inhibits the H+, K+ATPase (hydrogen-potassium adenosine triphosphatase) enzyme system located on the parietal cell secretory surface, inhibiting gastric acid secretion. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C80692 |
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| CAS_Registry |
117976-90-6 |
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| CHEBI_ID |
CHEBI:8769 |
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| Chemical_Formula |
C18H20N3O3S.Na |
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| code |
C80692 |
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| Contributing_Source |
FDA |
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| definition |
The sodium salt of the prodrug rabeprazole, a substituted benzimidazole proton pump inhibitor, with potential anti-ulcer activity. After protonation, accumulation, and transformation to the active sulfenamide within the acidic environment of gastric parietal cells, rabeprazole selectively and irreversibly binds to and inhibits the H+, K+ATPase (hydrogen-potassium adenosine triphosphatase) enzyme system located on the parietal cell secretory surface, inhibiting gastric acid secretion. |
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| FDA_UNII_Code |
3L36P16U4R |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Rabeprazole Sodium |
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| Legacy Concept Name |
Rabeprazole_Sodium |
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| NCI_Drug_Dictionary_ID |
641009 |
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| PDQ_Closed_Trial_Search_ID |
641009 |
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| PDQ_Open_Trial_Search_ID |
641009 |
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| Preferred_Name |
Rabeprazole Sodium |
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| prefixIRI |
NCIT:C80692 |
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| prefLabel |
Rabeprazole Sodium |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0732569 |
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| subClassOf |