loading...| Preferred Name |
Niraparib |
|
| Synonyms |
|
|
| Definitions |
An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C80059 |
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| CAS_Registry |
1038915-60-4 |
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| code |
C80059 |
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| Contributing_Source |
CTRP FDA |
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| definition |
An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. |
|
| Display_Name |
Niraparib |
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| FDA_UNII_Code |
HMC2H89N35 |
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Niraparib |
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| Legacy Concept Name |
PARP_Inhibitor_MK4827 |
|
| Maps_To |
Niraparib |
|
| NCI_Drug_Dictionary_ID |
615263 |
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| PDQ_Closed_Trial_Search_ID |
615263 |
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| PDQ_Open_Trial_Search_ID |
615263 |
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| Preferred_Name |
Niraparib |
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| prefixIRI |
NCIT:C80059 |
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| prefLabel |
Niraparib |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C2744440 |
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| subClassOf |