loading...| Preferred Name |
Regorafenib |
|
| Synonyms |
|
|
| Definitions |
The anhydrous form of regorafenib, an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C78204 |
|
| Accepted_Therapeutic_Use_For |
hepatocellular carcinoma (HCC) |
|
| CAS_Registry |
755037-03-7 |
|
| Chemical_Formula |
C21H15ClF4N4O3 |
|
| code |
C78204 |
|
| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
The anhydrous form of regorafenib, an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. |
|
| Display_Name |
Regorafenib |
|
| FDA_UNII_Code |
24T2A1DOYB |
|
| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C17484 http://purl.obolibrary.org/obo/NCIT_C26203 http://purl.obolibrary.org/obo/NCIT_C18539 http://purl.obolibrary.org/obo/NCIT_C17328 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C179531 http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C179478 |
|
| Is_Value_For_GDC_Property | ||
| label |
Regorafenib |
|
| Legacy Concept Name |
Multitargeted_Receptor_Tyrosine_Kinase_Inhibitor_BAY_73-4506 |
|
| Maps_To |
Regorafenib |
|
| NCI_Drug_Dictionary_ID |
595192 |
|
| PDQ_Closed_Trial_Search_ID |
595192 |
|
| PDQ_Open_Trial_Search_ID |
595192 |
|
| Preferred_Name |
Regorafenib |
|
| prefixIRI |
NCIT:C78204 |
|
| prefLabel |
Regorafenib |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C2980094 |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C1742 |