loading...| Preferred Name |
Therapeutic Progesterone |
|
| Synonyms |
|
|
| Definitions |
The therapeutic form of the naturally occurring hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C777 |
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| Accepted_Therapeutic_Use_For |
Amenorrhea; Functional uterine bleeding; Infertility; Maintenance of pregnancy |
|
| CAS_Registry |
57-83-0 |
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| CHEBI_ID |
CHEBI:59826 CHEBI:17026 |
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| Chemical_Formula |
C21H30O2 |
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| code |
C777 |
|
| Contributing_Source |
FDA |
|
| definition |
The therapeutic form of the naturally occurring hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. |
|
| FDA_UNII_Code |
4G7DS2Q64Y |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 |
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| Is_Related_To_Endogenous_Product | ||
| label |
Therapeutic Progesterone |
|
| Legacy Concept Name |
Therapeutic_Progesterone |
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| NCI_Drug_Dictionary_ID |
39059 |
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| NSC Number |
64377 9704 |
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| PDQ_Closed_Trial_Search_ID |
39059 |
|
| PDQ_Open_Trial_Search_ID |
39059 |
|
| Preferred_Name |
Therapeutic Progesterone |
|
| prefixIRI |
NCIT:C777 |
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| prefLabel |
Therapeutic Progesterone |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0591309 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C777 | NCIT | LOOM | |
| http://purl.bioontology.org/ontology/PDQ/CDR0000039059 | PDQ | LOOM |