loading...| Preferred Name |
Molgramostim |
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| Synonyms |
|
|
| Definitions |
A recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF), with potential immunostimulating activity. Upon administration as inhalation solution via nebulizer, molgramostim binds to specific cell surface receptors and promotes or restores GM-CSF signaling, thereby modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. This agent also activates neutrophils, monocytes, macrophages, and dendritic cells and promotes antigen presentation, upregulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin (IL)-2-mediated, lymphokine-activated killer cell function. In addition, the restoration of GM-CSF signaling promotes surfactant clearing by pulmonary alveolar macrophages. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C77591 |
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| CAS_Registry |
99283-10-0 |
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| code |
C77591 |
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| Contributing_Source |
FDA |
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| definition |
A recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF), with potential immunostimulating activity. Upon administration as inhalation solution via nebulizer, molgramostim binds to specific cell surface receptors and promotes or restores GM-CSF signaling, thereby modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. This agent also activates neutrophils, monocytes, macrophages, and dendritic cells and promotes antigen presentation, upregulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin (IL)-2-mediated, lymphokine-activated killer cell function. In addition, the restoration of GM-CSF signaling promotes surfactant clearing by pulmonary alveolar macrophages. |
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| FDA_UNII_Code |
B321AL142J |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Molgramostim |
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| Legacy Concept Name |
Molgramostim |
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| Preferred_Name |
Molgramostim |
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| prefixIRI |
NCIT:C77591 |
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| prefLabel |
Molgramostim |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0218633 |
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| subClassOf |