Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Carbenicillin Indanyl
Synonyms
Definitions

The indanyl ester of carbenicillin, a broad-spectrum, semisynthetic penicillin derivative with antibacterial activity. Following absorption, carbenicillin indanyl is rapidly hydrolyzed to the active carbenicillin, which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to a weakening of the bacterial cell wall, eventually causing bacterial cell lysis.
ID

http://purl.obolibrary.org/obo/NCIT_C76219
CAS_Registry

35531-88-5
CHEBI_ID

CHEBI:52015
Chemical_Formula

C26H26N2O6S
code

C76219
Contributing_Source

FDA
definition

The indanyl ester of carbenicillin, a broad-spectrum, semisynthetic penicillin derivative with antibacterial activity. Following absorption, carbenicillin indanyl is rapidly hydrolyzed to the active carbenicillin, which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to a weakening of the bacterial cell wall, eventually causing bacterial cell lysis.
FDA_UNII_Code

5V278481KE
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Carbenicillin Indanyl
Legacy Concept Name

Carbenicillin_Indanyl
Preferred_Name

Carbenicillin Indanyl
prefixIRI

NCIT:C76219
prefLabel

Carbenicillin Indanyl
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0054667
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1500
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