loading...| Preferred Name |
Recombinant Platelet-Derived Growth Factor |
|
| Synonyms |
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| Definitions |
Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that could bind to PDGF receptor and may elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C755 |
|
| code |
C755 |
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| definition |
Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that could bind to PDGF receptor and may elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI) |
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| label |
Recombinant Platelet-Derived Growth Factor |
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| Legacy Concept Name |
Therapeutic_Platlet-Derived_Growth_Factor |
|
| Preferred_Name |
Recombinant Platelet-Derived Growth Factor |
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| prefixIRI |
NCIT:C755 |
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| prefLabel |
Recombinant Platelet-Derived Growth Factor |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C1515387 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C755 | NCIT | LOOM | |
| http://doe-generated-ontology.com/OntoAD#C1515387 | ONTOAD | LOOM |