loading...| Preferred Name |
Dasatinib Anhydrous |
|
| Synonyms |
|
|
| Definitions |
An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C74556 |
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| CAS_Registry |
302962-49-8 |
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| CHEBI_ID |
CHEBI:49375 |
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| Chemical_Formula |
C22H26ClN7O2S |
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| code |
C74556 |
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| Contributing_Source |
CTRP FDA |
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| definition |
An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. |
|
| Display_Name |
Dasatinib Anhydrous |
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| FDA_UNII_Code |
X78UG0A0RN |
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| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C26156 http://purl.obolibrary.org/obo/NCIT_C17328 http://purl.obolibrary.org/obo/NCIT_C16325 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Dasatinib Anhydrous |
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| Legacy Concept Name |
Dasatinib_Anhydrous |
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| Preferred_Name |
Dasatinib Anhydrous |
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| prefixIRI |
NCIT:C74556 |
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| prefLabel |
Dasatinib Anhydrous |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C2699562 |
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| subClassOf |