loading...| Preferred Name |
Artesunate |
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| Synonyms |
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|
| Definitions |
A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C73005 |
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| CAS_Registry |
88495-63-0 |
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| CHEBI_ID |
CHEBI:63918 |
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| Chemical_Formula |
C19H28O8 |
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| code |
C73005 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua. |
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| Display_Name |
Artesunate |
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| FDA_UNII_Code |
60W3249T9M |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Artesunate |
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| Legacy Concept Name |
Artesunate |
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| Maps_To |
Artesunate |
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| NCI_Drug_Dictionary_ID |
617258 |
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| PDQ_Closed_Trial_Search_ID |
617258 |
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| PDQ_Open_Trial_Search_ID |
617258 |
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| Preferred_Name |
Artesunate |
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| prefixIRI |
NCIT:C73005 |
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| prefLabel |
Artesunate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0052432 |
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| subClassOf |