Preferred Name

Dexmedetomidine Hydrochloride
Synonyms
Definitions

The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.

ID

http://purl.obolibrary.org/obo/NCIT_C72738

CAS_Registry

145108-58-3

CHEBI_ID

CHEBI:31472

Chemical_Formula

C13H16N2.HCl

code

C72738

Contributing_Source

CTRP

FDA

definition

The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.

Display_Name

Dexmedetomidine Hydrochloride

FDA_UNII_Code

1018WH7F9I

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C47479

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

label

Dexmedetomidine Hydrochloride

Legacy Concept Name

Dexmedetomidine_Hydrochloride

NCI_Drug_Dictionary_ID

632933

PDQ_Closed_Trial_Search_ID

632933

PDQ_Open_Trial_Search_ID

632933

Preferred_Name

Dexmedetomidine Hydrochloride

prefixIRI

NCIT:C72738

prefLabel

Dexmedetomidine Hydrochloride

PubMedID_Primary_Reference

9227530

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0752310

subClassOf

http://purl.obolibrary.org/obo/NCIT_C29709

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