loading...| Preferred Name |
Enzalutamide |
|
| Synonyms |
|
|
| Definitions |
An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C71744 |
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| Accepted_Therapeutic_Use_For |
castration-resistant prostate cancer (CRPC) |
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| CAS_Registry |
915087-33-1 |
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| Chemical_Formula |
C21H16F4N4O2S |
|
| code |
C71744 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. |
|
| Display_Name |
Enzalutamide |
|
| FDA_UNII_Code |
93T0T9GKNU |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Enzalutamide |
|
| Legacy Concept Name |
Selective_Androgen_Receptor_Modulator_MDV3100 |
|
| Maps_To |
Enzalutamide |
|
| NCI_Drug_Dictionary_ID |
560774 |
|
| PDQ_Closed_Trial_Search_ID |
560774 |
|
| PDQ_Open_Trial_Search_ID |
560774 |
|
| Preferred_Name |
Enzalutamide |
|
| prefixIRI |
NCIT:C71744 |
|
| prefLabel |
Enzalutamide |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C2348174 |
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| subClassOf |