loading...| Preferred Name |
Pasireotide |
|
| Synonyms |
|
|
| Definitions |
A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting a much higher binding affinity for somatostatin receptors 1, 3, and 5 than octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. This agent is more potent than somatostatin in inhibiting the release of human growth hormone (HGH), glucagon, and insulin. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C69131 |
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| CAS_Registry |
396091-73-9 |
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| Chemical_Formula |
C58H66N10O9 |
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| code |
C69131 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting a much higher binding affinity for somatostatin receptors 1, 3, and 5 than octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. This agent is more potent than somatostatin in inhibiting the release of human growth hormone (HGH), glucagon, and insulin. |
|
| Display_Name |
Pasireotide |
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| FDA_UNII_Code |
98H1T17066 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
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| Is_Value_For_GDC_Property | ||
| label |
Pasireotide |
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| Legacy Concept Name |
Pasireotide |
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| Maps_To |
Pasireotide |
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| NCI_Drug_Dictionary_ID |
540440 |
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| PDQ_Closed_Trial_Search_ID |
540440 |
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| PDQ_Open_Trial_Search_ID |
540440 |
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| Preferred_Name |
Pasireotide |
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| prefixIRI |
NCIT:C69131 |
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| prefLabel |
Pasireotide |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C1872203 |
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| subClassOf |