loading...| Preferred Name |
Mitoxantrone Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C665 |
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| Accepted_Therapeutic_Use_For |
Acute Leukemia; Breast cancer; Non Hodgkins Lymphoma; Multiple sclerosis; Prostate cancer |
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| ALT_DEFINITION |
A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics. |
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| CAS_Registry |
70476-82-3 |
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| CHEBI_ID |
CHEBI:50727 |
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| Chemical_Formula |
C22H28N4O6.2HCl |
|
| code |
C665 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. |
|
| Display_Name |
Mitoxantrone Hydrochloride |
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| FDA_UNII_Code |
U6USW86RD0 |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Mitoxantrone Hydrochloride |
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| Legacy Concept Name |
Mitoxantrone |
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| Maps_To |
Mitoxantrone Hydrochloride |
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| NCI_Drug_Dictionary_ID |
39219 |
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| NSC Number |
301739 |
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| PDQ_Closed_Trial_Search_ID |
39219 |
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| PDQ_Open_Trial_Search_ID |
39219 |
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| Preferred_Name |
Mitoxantrone Hydrochloride |
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| prefixIRI |
NCIT:C665 |
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| prefLabel |
Mitoxantrone Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
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| UMLS_CUI |
C0700458 |
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| subClassOf |