loading...| Preferred Name |
Mitotane |
|
| Synonyms |
|
|
| Definitions |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C664 |
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| Accepted_Therapeutic_Use_For |
Adrenocortical carcinoma |
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| ALT_DEFINITION |
An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease). |
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| CAS_Registry |
53-19-0 |
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| Chemical_Formula |
C14H10Cl4 |
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| code |
C664 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04) |
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| Display_Name |
Mitotane |
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| FDA_UNII_Code |
78E4J5IB5J |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Mitotane |
|
| Legacy Concept Name |
Mitotane |
|
| Maps_To |
Mitotane |
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| NCI_Drug_Dictionary_ID |
39506 |
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| NSC Number |
38721 |
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| PDQ_Closed_Trial_Search_ID |
39506 |
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| PDQ_Open_Trial_Search_ID |
39506 |
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| Preferred_Name |
Mitotane |
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| prefixIRI |
NCIT:C664 |
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| prefLabel |
Mitotane |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0026256 |
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| subClassOf |