loading...| Preferred Name |
Phenprocoumon |
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| Synonyms |
|
|
| Definitions |
An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C66374 |
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| CAS_Registry |
435-97-2 |
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| CHEBI_ID |
CHEBI:50438 |
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| Chemical_Formula |
C18H16O3 |
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| code |
C66374 |
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| Contributing_Source |
FDA |
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| definition |
An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. |
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| FDA_UNII_Code |
Q08SIO485D |
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| in_subset | ||
| label |
Phenprocoumon |
|
| Legacy Concept Name |
Phenprocoumon |
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| NCI_Drug_Dictionary_ID |
750561 |
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| PDQ_Closed_Trial_Search_ID |
750561 |
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| PDQ_Open_Trial_Search_ID |
750561 |
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| Preferred_Name |
Phenprocoumon |
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| prefixIRI |
NCIT:C66374 |
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| prefLabel |
Phenprocoumon |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0031444 |
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| subClassOf |