loading...| Preferred Name |
Bitolterol |
|
| Synonyms |
|
|
| Definitions |
A diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C65267 |
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| CAS_Registry |
30392-40-6 |
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| CHEBI_ID |
CHEBI:3133 |
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| Chemical_Formula |
C28H31NO5 |
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| code |
C65267 |
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| Contributing_Source |
FDA |
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| definition |
A diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function. |
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| FDA_UNII_Code |
9KY0QXD6LI |
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Bitolterol |
|
| Legacy Concept Name |
Bitolterol |
|
| Preferred_Name |
Bitolterol |
|
| prefixIRI |
NCIT:C65267 |
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| prefLabel |
Bitolterol |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0053817 |
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| subClassOf |