loading...| Preferred Name |
Adalimumab |
|
| Synonyms |
|
|
| Definitions |
A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C65216 |
|
| Accepted_Therapeutic_Use_For |
Rheumatoid Arthritis, Crohn's Disease, Ankylosing Spondylitis, Psoriatic Arthritis |
|
| CAS_Registry |
331731-18-1 |
|
| code |
C65216 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases. |
|
| Display_Name |
Adalimumab |
|
| FDA_UNII_Code |
FYS6T7F842 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Adalimumab |
|
| Legacy Concept Name |
Adalimumab |
|
| NCI_Drug_Dictionary_ID |
791684 |
|
| PDQ_Closed_Trial_Search_ID |
791684 |
|
| PDQ_Open_Trial_Search_ID |
791684 |
|
| Preferred_Name |
Adalimumab |
|
| prefixIRI |
NCIT:C65216 |
|
| prefLabel |
Adalimumab |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1122087 |
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| subClassOf |