loading...| Preferred Name |
Labetalol Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C63578 |
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| CAS_Registry |
32780-64-6 |
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| Chemical_Formula |
C19H24N2O3.HCl |
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| code |
C63578 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. |
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| FDA_UNII_Code |
1GEV3BAW9J |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Labetalol Hydrochloride |
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| Legacy Concept Name |
Labetalol_Hydrochloride |
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| NSC Number |
290312 |
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| Preferred_Name |
Labetalol Hydrochloride |
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| prefixIRI |
NCIT:C63578 |
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| prefLabel |
Labetalol Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0699440 |
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| subClassOf |