loading...| Preferred Name |
Maytansine |
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| Synonyms |
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| Definitions |
An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C626 |
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| CAS_Registry |
35846-53-8 |
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| Chemical_Formula |
C34H46ClN3O10 |
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| code |
C626 |
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| Contributing_Source |
FDA |
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| definition |
An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04) |
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| FDA_UNII_Code |
14083FR882 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Maytansine |
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| Legacy Concept Name |
Maytansine |
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| Maps_To |
Maytansine |
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| NCI_Drug_Dictionary_ID |
39492 |
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| NSC Number |
153858 |
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| PDQ_Closed_Trial_Search_ID |
39492 |
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| PDQ_Open_Trial_Search_ID |
39492 |
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| Preferred_Name |
Maytansine |
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| prefixIRI |
NCIT:C626 |
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| prefLabel |
Maytansine |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0024975 |
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| subClassOf |