loading...| Preferred Name |
Radium Ra 223 Dichloride |
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| Synonyms |
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| Definitions |
A radiopharmaceutical composed of the dichloride salt of the alpha-emitting isotope radium Ra 223, with antineoplastic activity. Like calcium, radium targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases. Radium Ra 223 forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62535 |
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| CAS_Registry |
444811-40-9 |
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| Chemical_Formula |
2Cl.Ra |
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| code |
C62535 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A radiopharmaceutical composed of the dichloride salt of the alpha-emitting isotope radium Ra 223, with antineoplastic activity. Like calcium, radium targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases. Radium Ra 223 forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue. |
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| Display_Name |
Radium Ra 223 Dichloride |
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| FDA_UNII_Code |
RJ00KV3VTG |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Radium Ra 223 Dichloride |
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| Legacy Concept Name |
Radium-223 |
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| Maps_To |
Radium Ra 223 Dichloride |
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| NCI_Drug_Dictionary_ID |
749662 |
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| PDQ_Closed_Trial_Search_ID |
749662 |
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| PDQ_Open_Trial_Search_ID |
749662 |
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| Preferred_Name |
Radium Ra 223 Dichloride |
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| prefixIRI |
NCIT:C62535 |
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| prefLabel |
Radium Ra 223 Dichloride |
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| Semantic_Type |
Pharmacologic Substance Element, Ion, or Isotope |
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| UMLS_CUI |
C3541342 |
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| subClassOf |