loading...| Preferred Name |
Eltrombopag Olamine |
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| Synonyms |
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|
| Definitions |
The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C62501 |
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| Accepted_Therapeutic_Use_For |
Chronic Idiopathic Thrombocytopenic Purpura |
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| ALT_DEFINITION |
A drug used to treat chronic immune thrombocytopenic purpura (a condition in which platelets are destroyed by the immune system). It causes more platelets to be made in the bone marrow. It is also being studied in the treatment of low platelet counts caused by chemotherapy. It is a type of thrombopoietin receptor agonist. |
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| CAS_Registry |
496775-62-3 |
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| Chemical_Formula |
C25H22N4O4.2C2H7NO |
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| code |
C62501 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. |
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| Display_Name |
Eltrombopag Olamine |
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| FDA_UNII_Code |
4U07F515LG |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| label |
Eltrombopag Olamine |
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| Legacy Concept Name |
Eltrombopag |
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| NCI_Drug_Dictionary_ID |
420847 |
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| PDQ_Closed_Trial_Search_ID |
420847 |
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| PDQ_Open_Trial_Search_ID |
420847 |
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| Preferred_Name |
Eltrombopag Olamine |
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| prefixIRI |
NCIT:C62501 |
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| prefLabel |
Eltrombopag Olamine |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C1880492 |
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| subClassOf |