Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Thioguanine Anhydrous
Synonyms
Definitions

The anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis.
ID

http://purl.obolibrary.org/obo/NCIT_C61970
CAS_Registry

154-42-7
Chemical_Formula

C5H5N5S
code

C61970
Contributing_Source

FDA
definition

The anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis.
FDA_UNII_Code

WIX31ZPX66
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Thioguanine Anhydrous
Legacy Concept Name

Thioguanine_Anhydrous
Maps_To

Thioguanine Anhydrous
Preferred_Name

Thioguanine Anhydrous
prefixIRI

NCIT:C61970
prefLabel

Thioguanine Anhydrous
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1883309
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1556

http://purl.obolibrary.org/obo/NCIT_C2254
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