Preferred Name |
Fosfomycin |
|
Synonyms |
|
|
Definitions |
A phosphoenolpyruvate analogue and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties. Fosfomycin binds to and inactivates the enzyme enolpyruvate transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis and bacterial cell death. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C61772 |
|
CAS_Registry |
23155-02-4 |
|
CHEBI_ID |
CHEBI:28915 |
|
Chemical_Formula |
C3H7O4P |
|
code |
C61772 |
|
Contributing_Source |
FDA |
|
definition |
A phosphoenolpyruvate analogue and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties. Fosfomycin binds to and inactivates the enzyme enolpyruvate transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis and bacterial cell death. |
|
FDA_UNII_Code |
2N81MY12TE |
|
in_subset | ||
label |
Fosfomycin |
|
Legacy Concept Name |
Fosfomycin |
|
Preferred_Name |
Fosfomycin |
|
prefixIRI |
NCIT:C61772 |
|
prefLabel |
Fosfomycin |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0016610 |
|
subClassOf |