Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Fluvoxamine
Synonyms
Definitions

A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro.
ID

http://purl.obolibrary.org/obo/NCIT_C61769
ALT_DEFINITION

A drug used to treat obsessive-compulsive disorder. It is a type of antidepressant agent and selective serotonin reuptake inhibitor (SSRI).
CAS_Registry

54739-18-3
CHEBI_ID

CHEBI:5138
Chemical_Formula

C15H21F3N2O2
code

C61769
Contributing_Source

FDA
definition

A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro.
FDA_UNII_Code

O4L1XPO44W
Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C29063
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381
label

Fluvoxamine
Legacy Concept Name

Fluvoxamine
Preferred_Name

Fluvoxamine
prefixIRI

NCIT:C61769
prefLabel

Fluvoxamine
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0085228
subClassOf

http://purl.obolibrary.org/obo/NCIT_C94725

http://purl.obolibrary.org/obo/NCIT_C265
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http://purl.obolibrary.org/obo/CHEBI_5138 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 CHEBI LOOM
http://www.case.edu/EpilepsyOntology.owl#Fluvoxamine EPSO LOOM
http://stirdf.jst.go.jp/id/200907098234918389 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/N06AB08 ATC LOOM
https://go.drugbank.com/drugs/DB00176 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016666 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/42355 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000021981 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/003633 NDDF LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass0c4562a4_74ee_458f_89fd_1b962ee428b8 WWECA LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61769 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D016666 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0085228 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/5002-0034 CRISP LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060428 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Fluvoxamine GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 ODNAE LOOM
http://purl.bioontology.org/ontology/RCD/x01As RCD LOOM
http://www.case.edu/EpSO.owl#Fluvoxamine MEPO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15507 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016191 PMAPP-PMO LOOM
http://purl.jp/bio/4/id/200906011564757258 IOBC LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Fluvoxamine STMSO LOOM
http://scai.fraunhofer.de/AlzheimerOntology#fluvoxamine ADO LOOM
http://purl.bioontology.org/ontology/VANDF/4023976 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP14994-5 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372905008 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/OMIT_0017121 OMIT LOOM
http://www.drugbank.ca/drugs/DB00176 FTC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Fluvoxamine APAONTO LOOM
http://purl.bioontology.org/ontology/SNMI/C-62330 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.570.665.250 RH-MESH LOOM