Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Liposome-Encapsulated Doxorubicin Citrate
Synonyms
Definitions

A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile.
ID

http://purl.obolibrary.org/obo/NCIT_C61317
ALT_DEFINITION

A form of the anticancer drug doxorubicin citrate that is contained inside very tiny, fat-like particles. It is being studied in the treatment of breast cancer that has spread and in the treatment of other types of cancer. Doxorubicin citrate damages DNA and may kill cancer cells. Liposomal-encapsulated doxorubicin citrate may have fewer side effects and may work better than doxorubicin citrate.
CAS_Registry

111266-55-8
code

C61317
Contributing_Source

CTRP

FDA
definition

A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile.
Display_Name

Liposome-Encapsulated Doxorubicin Citrate
FDA_UNII_Code

AJQ2ZNG2WL
Has_Target

http://purl.obolibrary.org/obo/NCIT_C18434
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Liposome-Encapsulated Doxorubicin Citrate
Legacy Concept Name

Liposome-Encapsulated_Doxorubicin_Citrate
Maps_To

Liposome-Encapsulated Doxorubicin Citrate
NCI_Drug_Dictionary_ID

481301
PDQ_Closed_Trial_Search_ID

481301
PDQ_Open_Trial_Search_ID

481301
Preferred_Name

Liposome-Encapsulated Doxorubicin Citrate
prefixIRI

NCIT:C61317
prefLabel

Liposome-Encapsulated Doxorubicin Citrate
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1512062
subClassOf

http://purl.obolibrary.org/obo/NCIT_C67502
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