loading...| Preferred Name |
Isosorbide |
|
| Synonyms |
|
|
| Definitions |
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C60773 |
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| CAS_Registry |
652-67-5 |
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| Chemical_Formula |
C6H10O4 |
|
| code |
C60773 |
|
| Contributing_Source |
FDA |
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| definition |
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. |
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| FDA_UNII_Code |
WXR179L51S |
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset | ||
| label |
Isosorbide |
|
| Legacy Concept Name |
Isosorbide |
|
| NSC Number |
40725 |
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| Preferred_Name |
Isosorbide |
|
| prefixIRI |
NCIT:C60773 |
|
| prefLabel |
Isosorbide |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0022251 |
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| subClassOf |