loading...| Preferred Name |
Integrin Alpha-V |
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| Synonyms |
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| Definitions |
Integrin alpha-V (1148 aa, ~116 kDa) is encoded by the human ITGAV gene. This protein plays a role in cell-matrix adhesion and pathological angiogenesis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C53961 |
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| code |
C53961 |
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| Contributing_Source |
CTRP |
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| definition |
Integrin alpha-V (1148 aa, ~116 kDa) is encoded by the human ITGAV gene. This protein plays a role in cell-matrix adhesion and pathological angiogenesis. |
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| DesignNote |
Human integrin alpha-V protein is a type I membrane protein that forms a heterodimer with an integrin beta protein (either the beta-1, 3, 5, 6 or 8 polypeptide). The resulting complex binds to the tripeptide R-G-D, an amino acid sequence present in a number of ligands including vitronectin, fibronectin, fibrinogen, and laminin. Ligand binding regulates cell adhesion, growth and migration. |
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| Display_Name |
Integrin Alpha-V |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Integrin Alpha-V |
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| Legacy Concept Name |
ITGAV_Protein |
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| OMIM_Number |
193210 |
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| Preferred_Name |
Integrin Alpha-V |
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| prefixIRI |
NCIT:C53961 |
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| prefLabel |
Integrin Alpha-V |
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| Semantic_Type |
Amino Acid, Peptide, or Protein |
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| Swiss_Prot |
P06756 |
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| UMLS_CUI |
C0253930 |
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| subClassOf |