Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Levonorgestrel-Releasing Intrauterine System
Synonyms
Definitions

A long-acting, hormone-releasing, intrauterine device consisting of a small, T-shaped, polyethylene frame and a reservoired synthetic progesterone with progestational and potential antineoplastic activities. After insertion of this system into the uterus, the device slowly and gradually releases the hormone. Levonorgestrel acts by binding to the progesterone receptor in the nuclei of target cells, resulting in transcription activation and an alteration in protein synthesis. Subsequently, luteinizing hormone (LH) activity and ovulation are suppressed. Levonorgestrel may also exhibit antiproliferative activity in endometrial tissue.
ID

http://purl.obolibrary.org/obo/NCIT_C52193
code

C52193
Contributing_Source

CTRP
definition

A long-acting, hormone-releasing, intrauterine device consisting of a small, T-shaped, polyethylene frame and a reservoired synthetic progesterone with progestational and potential antineoplastic activities. After insertion of this system into the uterus, the device slowly and gradually releases the hormone. Levonorgestrel acts by binding to the progesterone receptor in the nuclei of target cells, resulting in transcription activation and an alteration in protein synthesis. Subsequently, luteinizing hormone (LH) activity and ovulation are suppressed. Levonorgestrel may also exhibit antiproliferative activity in endometrial tissue.
Display_Name

Levonorgestrel-Releasing Intrauterine System
Has_Target

http://purl.obolibrary.org/obo/NCIT_C17075
in_subset

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
label

Levonorgestrel-Releasing Intrauterine System
Legacy Concept Name

Levonorgestrel-Releasing_Intrauterine_System
NCI_Drug_Dictionary_ID

459975
PDQ_Closed_Trial_Search_ID

459975
PDQ_Open_Trial_Search_ID

459975
Preferred_Name

Levonorgestrel-Releasing Intrauterine System
prefixIRI

NCIT:C52193
prefLabel

Levonorgestrel-Releasing Intrauterine System
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0591811
subClassOf

http://purl.obolibrary.org/obo/NCIT_C184790
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