loading...| Preferred Name |
Prilocaine Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C48012 |
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| CAS_Registry |
1786-81-8 |
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| CHEBI_ID |
CHEBI:32053 |
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| Chemical_Formula |
C13H20N2O.HCl |
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| code |
C48012 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. |
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| FDA_UNII_Code |
MJW015BAPH |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Prilocaine Hydrochloride |
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| Legacy Concept Name |
Prilocaine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
709375 |
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| PDQ_Closed_Trial_Search_ID |
709375 |
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| PDQ_Open_Trial_Search_ID |
709375 |
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| Preferred_Name |
Prilocaine Hydrochloride |
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| prefixIRI |
NCIT:C48012 |
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| prefLabel |
Prilocaine Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0008846 |
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| subClassOf |