loading...| Preferred Name |
Albuterol Sulfate |
|
| Synonyms |
|
|
| Definitions |
The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47957 |
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| CAS_Registry |
51022-70-9 |
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| CHEBI_ID |
CHEBI:2550 |
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| Chemical_Formula |
2C13H21NO3.H2O4S |
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| code |
C47957 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction. |
|
| Display_Name |
Albuterol Sulfate |
|
| FDA_UNII_Code |
021SEF3731 |
|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Albuterol Sulfate |
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| Legacy Concept Name |
Albuterol_Sulfate |
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| NCI_Drug_Dictionary_ID |
41339 |
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| NSC Number |
289928 |
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| PDQ_Closed_Trial_Search_ID |
41339 |
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| PDQ_Open_Trial_Search_ID |
41339 |
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| Preferred_Name |
Albuterol Sulfate |
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| prefixIRI |
NCIT:C47957 |
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| prefLabel |
Albuterol Sulfate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0543495 |
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| subClassOf |