Preferred Name |
Tranexamic Acid |
|
Synonyms |
|
|
Definitions |
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C47765 |
|
CAS_Registry |
1197-18-8 |
|
CHEBI_ID |
CHEBI:48669 |
|
Chemical_Formula |
C8H15NO2 |
|
code |
C47765 |
|
Contributing_Source |
FDA |
|
definition |
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action. |
|
FDA_UNII_Code |
6T84R30KC1 |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 |
|
label |
Tranexamic Acid |
|
Legacy Concept Name |
Tranexamic_Acid |
|
NCI_Drug_Dictionary_ID |
453549 |
|
NSC Number |
291305 |
|
PDQ_Closed_Trial_Search_ID |
453549 |
|
PDQ_Open_Trial_Search_ID |
453549 |
|
Preferred_Name |
Tranexamic Acid |
|
prefixIRI |
NCIT:C47765 |
|
prefLabel |
Tranexamic Acid |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0040613 |
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subClassOf |