loading...| Preferred Name |
Tiopronin |
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| Synonyms |
|
|
| Definitions |
An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47758 |
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| CAS_Registry |
1953-02-2 |
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| Chemical_Formula |
C5H9NO3S |
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| code |
C47758 |
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| Contributing_Source |
FDA |
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| definition |
An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. |
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| FDA_UNII_Code |
C5W04GO61S |
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| in_subset | ||
| label |
Tiopronin |
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| Legacy Concept Name |
Tiopronin |
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| Preferred_Name |
Tiopronin |
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| prefixIRI |
NCIT:C47758 |
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| prefLabel |
Tiopronin |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0025405 |
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| subClassOf |