Preferred Name |
Timolol |
|
Synonyms |
|
|
Definitions |
A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C47757 |
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CAS_Registry |
91524-16-2 |
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CHEBI_ID |
CHEBI:60787 |
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Chemical_Formula |
2C13H24N4O3S.H2O |
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code |
C47757 |
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Contributing_Source |
FDA |
|
definition |
A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis. |
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FDA_UNII_Code |
817W3C6175 |
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Has_Salt_Form | ||
in_subset | ||
label |
Timolol |
|
Legacy Concept Name |
Timolol |
|
Preferred_Name |
Timolol |
|
prefixIRI |
NCIT:C47757 |
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prefLabel |
Timolol |
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Semantic_Type |
Pharmacologic Substance |
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UMLS_CUI |
C0040233 |
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subClassOf |