loading...| Preferred Name |
Paromomycin Sulfate |
|
| Synonyms |
|
|
| Definitions |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47652 |
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| CAS_Registry |
1263-89-4 |
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| CHEBI_ID |
CHEBI:7935 |
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| Chemical_Formula |
C23H45N5O14.H2SO4 |
|
| code |
C47652 |
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| Contributing_Source |
FDA |
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| definition |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. |
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| FDA_UNII_Code |
845NU6GJPS |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Paromomycin Sulfate |
|
| Legacy Concept Name |
Paromomycin_Sulfate |
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| NCI_Drug_Dictionary_ID |
769609 |
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| NSC Number |
227228 |
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| PDQ_Closed_Trial_Search_ID |
769609 |
|
| PDQ_Open_Trial_Search_ID |
769609 |
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| Preferred_Name |
Paromomycin Sulfate |
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| prefixIRI |
NCIT:C47652 |
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| prefLabel |
Paromomycin Sulfate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0205881 |
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| subClassOf |