loading...| Preferred Name |
Enalapril Maleate |
|
| Synonyms |
|
|
| Definitions |
The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C468 |
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| CAS_Registry |
76095-16-4 |
|
| CHEBI_ID |
CHEBI:4785 |
|
| Chemical_Formula |
C20H28N2O5.C4H4O4 |
|
| code |
C468 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| Display_Name |
Enalapril Maleate |
|
| FDA_UNII_Code |
9O25354EPJ |
|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Enalapril Maleate |
|
| Legacy Concept Name |
Enalapril |
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| NCI_Drug_Dictionary_ID |
42544 |
|
| PDQ_Closed_Trial_Search_ID |
42544 |
|
| PDQ_Open_Trial_Search_ID |
42544 |
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| Preferred_Name |
Enalapril Maleate |
|
| prefixIRI |
NCIT:C468 |
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| prefLabel |
Enalapril Maleate |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0700452 |
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| subClassOf |