Preferred Name |
Phenoxybenzamine Hydrochloride |
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Synonyms |
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Definitions |
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
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ID |
http://purl.obolibrary.org/obo/NCIT_C44435 |
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CAS_Registry |
63-92-3 |
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Chemical_Formula |
C18H22ClNO.HCl |
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code |
C44435 |
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Contributing_Source |
FDA |
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definition |
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
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FDA_UNII_Code |
X1IEG24OHL |
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Has_Free_Acid_Or_Base_Form | ||
in_subset | ||
label |
Phenoxybenzamine Hydrochloride |
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Legacy Concept Name |
Phenoxybenzamine |
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NCI_Drug_Dictionary_ID |
703206 |
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NSC Number |
37448 |
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PDQ_Closed_Trial_Search_ID |
703206 |
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PDQ_Open_Trial_Search_ID |
703206 |
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Preferred_Name |
Phenoxybenzamine Hydrochloride |
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prefixIRI |
NCIT:C44435 |
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prefLabel |
Phenoxybenzamine Hydrochloride |
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Semantic_Type |
Pharmacologic Substance |
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UMLS_CUI |
C0701367 |
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subClassOf |