loading...| Preferred Name |
Cyclosporine |
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| Synonyms |
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| Definitions |
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C406 |
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| Accepted_Therapeutic_Use_For |
Allogenic transplants; prophylaxis of organ rejection in bone marrow; kidney; liver and heart transplants; psoriasis; rheumatoid arthritis; various diseases that involve autoimmune response |
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| ALT_DEFINITION |
A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs. |
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| CAS_Registry |
59865-13-3 |
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| CHEBI_ID |
CHEBI:4031 |
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| Chemical_Formula |
C62H111N11O12 |
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| code |
C406 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04) |
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| Display_Name |
Cyclosporine |
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| FDA_UNII_Code |
83HN0GTJ6D |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
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| Is_Value_For_GDC_Property | ||
| label |
Cyclosporine |
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| Legacy Concept Name |
Cyclosporine |
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| Maps_To |
Cyclosporine |
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| NCI_Drug_Dictionary_ID |
39201 |
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| NSC Number |
290193 |
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| PDQ_Closed_Trial_Search_ID |
39201 |
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| PDQ_Open_Trial_Search_ID |
39201 |
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| Preferred_Name |
Cyclosporine |
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| prefixIRI |
NCIT:C406 |
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| prefLabel |
Cyclosporine |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0010592 |
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| subClassOf |