loading...| Preferred Name |
Phentolamine Mesylate |
|
| Synonyms |
|
|
| Definitions |
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C38691 |
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| Accepted_Therapeutic_Use_For |
Dermal necrosis; Hypertensive-associated episodes with pheochromocytoma, prevention or control |
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| CAS_Registry |
65-28-1 |
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| Chemical_Formula |
C17H19N3O.CH4O3S |
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| code |
C38691 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
| Display_Name |
Phentolamine Mesylate |
|
| FDA_UNII_Code |
Y7543E5K9T |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Phentolamine Mesylate |
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| Legacy Concept Name |
Phentolamine |
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| NCI_Drug_Dictionary_ID |
360460 |
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| PDQ_Closed_Trial_Search_ID |
360460 |
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| PDQ_Open_Trial_Search_ID |
360460 |
|
| Preferred_Name |
Phentolamine Mesylate |
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| prefixIRI |
NCIT:C38691 |
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| prefLabel |
Phentolamine Mesylate |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0733398 |
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| subClassOf |