loading...| Preferred Name |
Nimesulide |
|
| Synonyms |
|
|
| Definitions |
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29842 |
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| CAS_Registry |
51803-78-2 |
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| CHEBI_ID |
CHEBI:44445 |
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| Chemical_Formula |
C13H12N2O5S |
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| code |
C29842 |
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| Contributing_Source |
FDA |
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| definition |
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04) |
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| FDA_UNII_Code |
V4TKW1454M |
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| in_subset | ||
| label |
Nimesulide |
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| Legacy Concept Name |
Nimesulide |
|
| Preferred_Name |
Nimesulide |
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| prefixIRI |
NCIT:C29842 |
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| prefLabel |
Nimesulide |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0132515 |
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| subClassOf |