loading...| Preferred Name |
Timolol Maleate |
|
| Synonyms |
|
|
| Definitions |
The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29501 |
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| CAS_Registry |
26921-17-5 |
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| CHEBI_ID |
CHEBI:9600 |
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| Chemical_Formula |
C13H24N4O3S.C4H4O4 |
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| code |
C29501 |
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| Contributing_Source |
FDA |
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| definition |
The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis. |
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| FDA_UNII_Code |
P8Y54F701R |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Timolol Maleate |
|
| Legacy Concept Name |
Timolol_Maleate |
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| NCI_Drug_Dictionary_ID |
803210 |
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| PDQ_Closed_Trial_Search_ID |
803210 |
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| PDQ_Open_Trial_Search_ID |
803210 |
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| Preferred_Name |
Timolol Maleate |
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| prefixIRI |
NCIT:C29501 |
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| prefLabel |
Timolol Maleate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0087093 |
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| subClassOf |