loading...| Preferred Name |
Mycophenolate |
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| Synonyms |
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| Definitions |
The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29272 |
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| CHEBI_ID |
CHEBI:62932 |
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| code |
C29272 |
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| definition |
The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04) |
|
| label |
Mycophenolate |
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| Legacy Concept Name |
Mycophenolate |
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| Preferred_Name |
Mycophenolate |
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| prefixIRI |
NCIT:C29272 |
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| prefLabel |
Mycophenolate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0883242 |
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| subClassOf |