loading...| Preferred Name |
Moexipril Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt form of moexipril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moexipril hydrochloride is hydrolized into its active form moexiprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilatation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Moexipril hydrochloride also directly suppresses renin release. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29267 |
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| CAS_Registry |
82586-52-5 |
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| Chemical_Formula |
C27H34N2O7.HCl |
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| code |
C29267 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride salt form of moexipril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moexipril hydrochloride is hydrolized into its active form moexiprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilatation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Moexipril hydrochloride also directly suppresses renin release. |
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| FDA_UNII_Code |
Q1UMG3UH45 |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Moexipril Hydrochloride |
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| Legacy Concept Name |
Moexipril_Hydrochloride |
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| Preferred_Name |
Moexipril Hydrochloride |
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| prefixIRI |
NCIT:C29267 |
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| prefLabel |
Moexipril Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0771294 |
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| subClassOf |